Taurr Am J Obstet Gynecol. Case-control study of cancer of the vulva. How to cite this article. Vulvoscopy in benign and premalignant vulvar lesions: Am J Surg Pathol.
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For slowly renewing tissues, this method provides a better estimate of the average age of the tissue than direct estimate from the bomb curve. Human tissues continually replace dying cells with newborn cells. Biological processes span several scales in space, from the single molecules to organisms and ecosystems. We have developed a mathematical method to estimate cell turnover in slowly renewing biological systems.
Estimating cell turnover research theme Human tissues continually replace dying cells with newborn cells. We use a simple cell population model to study how biological rhythms and the cell cycle interact to modulate the response to cancer therapy.
A better understanding of the dyamical feature of clock regulation is important for designing individualized chronotherapy treatments. However, the rate of renewal varies by orders of magnitudes between blood cells, which are renewed every day and neurons, for which renewal is non-existent or limited to specific regions of the brain. Multiscale modelling approaches in biology are useful to take into account the complex interactions between different organisation levels in those systems.
Chronotherapy of cancers aims at exploiting daily physiological rhythms to improve anti-cancer efficacy and tolerance to drugs by administering treatments at a specific time each esercices.
Chronotherapy of cancer research theme Chronotherapy of cancers aims at exploiting daily physiological rhythms to improve anti-cancer efficacy and tolerance to drugs by administering treatments at a specific time each day. A theoretical basis for the rational development of individualized therapy schedules is still lacking. Age distribution of DNA can be lindaire from the integration of radiocarbon derived from nuclear bomb testing during Multiscale modelling research theme Biological processes span several scales in space, from the single molecules to organisms and ecosystems.
Recent clinical trials have shown that chronotherapy can be beneficial in improving quality of life and median life span in patients, but that it can also have negative effects if the timing is wrong. Moreover, death, birth and turnover rates can be estimated. Most 10 Related.
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